CHEM4524

Chemistry 4524 is the second semester of a 2-semester sequence in organic chemistry starting with Chemistry 3514. Unlike the first semester, the chief goal will be to provide students a wide sampling of the varieties of chemistries associated with key functionalities. Lecture topics include: synthetic routes to and from unsaturated aliphatics, notably: alkenes, alkynes, allylic and alkadienes with emphasis on accompanying mechanistic pictures notably: radical and carbocation additions, concerted additions, radical substitutions: synthetic routes to and from substituted aromatic compounds with emphasis on the electrophilic substitution mechanism; synthetic routes to and from carbonyl compounds including: aldehydes, ketones, carboxylic acids and their derivatives with particular focus on the special role played by the beta hydrogen; a brief survey of reactions and properties of amines, ester enolates, and a survey of carbohydrate structure and chemistry. A thorough introduction to stereochemical language not covered in the first semester is also carried out. Lab topics include mastery of organic techniques not covered in the first semester, e.g. NMR and polarimetry, mass spectroscopy and, hands-on experience with the various reactions discussed in lecture, notably: ring substitution, cycloaddition, stereo addition, carbonyl condensations, and esterification.